7/28/2023 0 Comments Banner thunderbird diabetesThis article describes how engineered microbes self-regulate the expression of target proteins according to the surrounding environment. Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Functional heterologous protein expression by genetically engineered probiotic yeast Saccharomyces boulardii. In situ biomanufacturing of small molecules in the mammalian gut by probiotic Saccharomyces boulardii. Engineer probiotic bifidobacteria for food and biomedical applications - current status and future prospective. Accessing the inaccessible: molecular tools for bifidobacteria. Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome. Engineering bacteria for diagnostic and therapeutic applications. Synthetic biology tools to engineer microbial communities for biotechnology. A unified catalog of 204,938 reference genomes from the human gut microbiome. A new genomic blueprint of the human gut microbiota. Colitogenic Bacteroides thetaiotaomicron antigens access host immune cells in a sulfatase-dependent manner via outer membrane vesicles. Use of bioengineered human commensal gut bacteria-derived microvesicles for mucosal plague vaccine delivery and immunization. In situ delivery and production system (iDPS) of anti-cancer molecules with gene-engineered bifidobacterium. Probiotic strains detect and suppress cholera in mice. Engineered lactobacilli display anti-biofilm and growth suppressing activities against Pseudomonas aeruginosa. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. CRISPR interference for rapid knockdown of essential cell cycle genes in Lactobacillus plantarum. Development of a RecE/T-assisted CRISPR–Cas9 toolbox for Lactobacillus. Portable CRISPR-Cas9(N) system for flexible genome engineering in Lactobacillus acidophilus, Lactobacillus gasseri, and Lactobacillus paracasei. CRISPR/Cas9-assisted seamless genome editing in Lactobacillus plantarum and its application in N-acetylglucosamine production. ![]() Genome editing using the endogenous type I CRISPR–Cas system in Lactobacillus crispatus. Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study. Safety and pharmacodynamics of an engineered E. ![]() Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering. Engineered Escherichia coli Nissle 1917 with urate oxidase and an oxygen-recycling system for hyperuricemia treatment. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans. Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Guild-based analysis for understanding gut microbiome in human health and diseases. Engineered bacteria as therapeutic agents. The gut microbiota - masters of host development and physiology. Structure, function and diversity of the healthy human microbiome. Massive expansion of human gut bacteriophage diversity. F., Almeida, A., Rangel-Pineros, G., Finn, R. Emerging technologies for gut microbiome research. Brain–gut–microbe communication in health and disease. Microbes in gastrointestinal health and disease. ![]() Understanding the holobiont: how microbial metabolites affect human health and shape the immune system. Urbanization and the gut microbiota in health and inflammatory bowel disease. This article reviews the role of the gut microbiome in human health and disease. The human intestinal microbiome in health and disease.
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